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Formation of new capillary-like tubes in a three-dimensional in vitro model (Aorta/Collagen Gel)
Ist Teil von
Annals of anatomy, 1997-04, Vol.179 (2), p.137-147
Ort / Verlag
Germany: Elsevier GmbH
Erscheinungsjahr
1997
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
Direct sprouting (angiogenesis) does not occur during the formation of capillary-like tubes in an aorta/ collagen gel in the in vitro model. However, emigration of cells which stretch, arrange themselves side by side, form contacts (unspecific, tight and gap junctions), develop a lumen and show differentiation of endothelial cells (including the formation of a lamina densa and the appearance of pericytes) have been observed, i. e. vasculo genesis occurs. The origin of long, stretched cells is not known with certainty. They possibly represent smooth muscle cells. In addition, other cell types have been found, such as fibrocyte-like and fibroblast-like cells, elas toblasts, fat cells, monocytes and macrophages. All these cells are able to produce factors that promote the formation of new capillaries. Hence, a knowledge of these cells appears to be important for the analysis of in vitro systems. Moreover, the occurrence of these cell types must be considered when assessing possible effects.