Details

Autor(en) / Beteiligte

• Rabkin, Charles S
• Janz, Siegfried
• Lash, Alex
• Coleman, Allen E
• Musaba, Elizabeth
• Liotta, Lance
• Biggar, Robert J
• Zhuang, Zhengping

Titel

Monoclonal Origin of Multicentric Kaposi's Sarcoma Lesions

Ist Teil von

• The New England journal of medicine, 1997-04, Vol.336 (14), p.988-993

Ort / Verlag

Boston, MA: Massachusetts Medical Society

Erscheinungsjahr

1997

Quelle

EZB-FREE-00999 freely available EZB journals

Beschreibungen/Notizen

• Kaposi's sarcoma is the most common tumor in patients with the acquired immunodeficiency syndrome (AIDS). 1 , 2 The lesions associated with the disease have four characteristic components: thin-walled neovascular formations, extravasated red cells, inflammatory lymphocytes, and proliferating spindle cells. The spindle cells, which may be the primary abnormality, are more prominent in nodular tumors than in plaque or patch lesions. Although their origin is unknown, spindle cells have the characteristic immunohistochemical and ultrastructural features of endothelial cells. 3 , 4 The neoplastic or hyperplastic nature of spindle cells has long been debated, 5 , 6 but the demonstration that individual Kaposi's sarcoma lesions are clonal . . .