Details

Autor(en) / Beteiligte

• Rideau, Nicole
• Simon, Jean

Titel

Delayed and atypical d-glyceraldehyde-induced insulin secretion from the perfused duodenum pancreas of chicken

Ist Teil von

• General and comparative endocrinology, 1989, Vol.73 (1), p.129-135

Ort / Verlag

San Diego, CA: Elsevier Inc

Erscheinungsjahr

1989

Quelle

Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)

Beschreibungen/Notizen

• Insulin release by the isolated-perfused pancreas of 5–8 week-old chickens was studied in response to graded concentrations of d-glyceraldehyde ( d-GA) (5–20 m M). d-GA was perfused for 30 min in the absence or in the presence of glucose concentrations (2.8 or 14 m M) which do not evoke insulin release alone. d-GA alone or in combination with glucose does not cause a biphasic insulin release. As compared to rodents the release is reduced and delayed (at least 16 min) and requires higher d-GA concentrations which reveals the insensitivity of the chicken pancreas to d-GA. In the absence of glucose, the release is higher at 15 m M d-GA. Glucose (2.8 or 14 m M) sensitized the pancreas to d-GA by eliciting earlier and higher insulin response but never restored an immediate and biphasic secretory response to d-GA. Glucose amplified the response to low d-GA levels (5 and 10 m M) and inhibited the response to higher concentrations (15 and 20 m M). A transient insulin rise (“off-response”) related to the d-GA concentration was observed after withdrawal of d-GA either in the absence or in the presence of glucose. Therefore, in addition to glucose, the chicken pancreas is relatively insensitive to d-GA suggesting that the mechanism leading to insulin release in response to nutrient metabolism is different in chickens as compared to that in mammals.