Toxicology letters, 1997-02, Vol.90 (2), p.207-216
1997
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Details
- Autor(en) / Beteiligte
- Titel
- Evidence for nitric oxide participation in down-regulation of CYP2B1/2 gene expression at the pretranslational level
- Ist Teil von
- Toxicology letters, 1997-02, Vol.90 (2), p.207-216
- Ort / Verlag
- Shannon: Elsevier Ireland Ltd
- Erscheinungsjahr
- 1997
- Quelle
- Access via ScienceDirect (Elsevier)
- Beschreibungen/Notizen
- Septic or inflammatory stimuli suppress drug metabolism by cytochrome P-450 in the liver, presumably at the pretranslational level. We have shown previously that nitric oxide is responsible at least in part for the inhibition by bacterial lipopolysaccharide of phenobarbital-induced CYP2B1/2 activity in vivo. This was attributed to the interaction of nitric oxide with heme in the active-center of cytochrome P450, leading to enzyme inactivation. Here, we report of nitric oxide with heme in the active-center of cytochrome P450, leading to enzyme inactivation. Here, we report that endogeneous nitric oxide also contributes to LPS-induced suppression of CYP2B1/2 in vivo by down-regulating the expression of CYP2B1/2 protein and mRNA.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0378-4274eISSN: 1879-3169DOI: 10.1016/S0378-4274(96)03857-XTitel-ID: cdi_proquest_miscellaneous_78868520
- Format
- –
- Schlagworte
- Animals, Aryl Hydrocarbon Hydroxylases, Biological and medical sciences, Chemical and industrial products toxicology. Toxic occupational diseases, CYP2B expression, Cytochrome P-450 CYP2B1 - drug effects, Cytochrome P-450 CYP2B1 - genetics, Cytochrome P-450 Enzyme System - drug effects, Cytochrome P-450 Enzyme System - genetics, Down-Regulation - drug effects, Gene Expression Regulation - drug effects, Male, Medical sciences, Metals and various inorganic compounds, Nitric oxide, Nitric Oxide - physiology, Protein Biosynthesis - drug effects, Rat, Rats, Rats, Wistar, Steroid Hydroxylases - drug effects, Steroid Hydroxylases - genetics, Toxicology