Details

Autor(en) / Beteiligte

• Epstein, C.M.
• Trotter, J.F.
• Averbook, A.
• Freeman, S.
• Kutner, M.H.
• Elsas, L.J.

Titel

EEG mean frequencies are sensitive indices of phenylalanine effects on normal brain

Ist Teil von

• Electroencephalography and clinical neurophysiology, 1989-02, Vol.72 (2), p.133-139

Ort / Verlag

Shannon: Elsevier Ireland Ltd

Erscheinungsjahr

1989

Quelle

Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)

Beschreibungen/Notizen

• We previously reported that changes in plasma phenylalanine (PHE) concentrations of 1000 μM or more adversely affected cognitive function and reduced mean frequency of the EEG power spectrum. In the present study, we characterized EEG effects of changes in plasma PHE from physiological to supraphysiological concentrations. Subjects were mentally normal children and adult volunteers with 3 different genotypes for phenylalanine hydroxylase (PHY): homozygous deficient, heterozygous, and homozygous normal. Double-blinded crossover studies were performed at equilibrium during PHE restriction and supplementation. The mean frequency of the power spectrum and the mean across a set of alpha-theta factors showed highly significant, reversible, generalized EEG slowing during PHE supplementation in subjects homozyous for PHY deficiency. Smaller but significant changes in EEg mean frequencies occurred in the heterozygous and normal subjects. Spectral profiles of EEG change were similar in both groups; the mean alpha-theta was more sensitive in the second group. Demonstration of EEG changes with PHE supplementation in normal individuals has important dietary implications.