Biochemical pharmacology, 1997-01, Vol.53 (2), p.135-140
1997
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Details
- Autor(en) / Beteiligte
- Titel
- Effects of piracetam on membrane fluidity in the aged mouse, rat, and human brain
- Ist Teil von
- Biochemical pharmacology, 1997-01, Vol.53 (2), p.135-140
- Ort / Verlag
- New York, NY: Elsevier Inc
- Erscheinungsjahr
- 1997
- Quelle
- Access via ScienceDirect (Elsevier)
- Beschreibungen/Notizen
- In vitro preincubation of brain membranes of aged mice wirh piracetam (0.1–1.0 mmol/L) enhanced membrane fluidity, as indicated by decreased anisotropy of the membrane-bound fluorescence probe 1,6-diphenyl-1,3,5-hexatriene (DPH). Piracetam had similar in vitro effects on brain membranes of aged rats and humans, but it did not alter brain membrane fluidity in young mice. Chronic treatment of young and aged rats with piracetam (300 mg/kg once daily) significantly increased membrane fluidity in some brain regions of the aged animals, but had no measurable effect on membrane fluidity in the young rats. The same treatment significantly improved active avoidance learning in the aged rats only. It is suggested that some of the pharmacological properties of piracetam can be explained by its effects on membrane fluidity.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0006-2952eISSN: 1873-2968DOI: 10.1016/S0006-2952(96)00463-7Titel-ID: cdi_proquest_miscellaneous_78835843
- Format
- –
- Schlagworte
- Aged, aging, Aging - physiology, Animals, Biological and medical sciences, Brain - drug effects, cognitive functions, Female, fluidity, Humans, Male, Medical sciences, membrane, Membrane Fluidity - drug effects, Mice, Neuropharmacology, Neuroprotective Agents - pharmacology, Pharmacology. Drug treatments, piracetam, Piracetam - pharmacology, Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease), Psychology. Psychoanalysis. Psychiatry, Psychopharmacology, Rats, Rats, Wistar