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Activation and function of natural killer cell responses during viral infections
Ist Teil von
Current opinion in immunology, 1997-02, Vol.9 (1), p.24-34
Ort / Verlag
England: Elsevier Ltd
Erscheinungsjahr
1997
Link zum Volltext
Quelle
Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)
Beschreibungen/Notizen
Although the role of natural killer (NK) cells in defense against certain viral infections has been appreciated for a number of years, characterization of the virus-induced endogenous mechanisms regulating NK cell responses and functions has been limited to interferon (IFN)-α/β-mediated activation of NK cell cytotoxicity. Studies of experimental infections have demonstrated that virus-induced NK cells undergo blastogenesis and can be activated to produce IFN-γ. Recent work has shown that some, but not all, viral infections induce IL-12, the expression of which results in NK cell IFN-γ production, and that NK cell IFN-γ production contributes to an antiviral state. IL-12 expression can be regulated by IFN-α/β, and endogenous IFN-α/β is responsible for the lack of IL-12 during viral infections that fail to elicit detectable production of this factor. Once T cell responses are activated, additional mechanisms are in place to turn off NK cell functions. These studies demonstrate that viral infections elicit unique mechanisms for regulating NK cell responses, and suggest that the host requires tight control of NK cells under these conditions.