Details

Autor(en) / Beteiligte

• George, M S
• Ketter, T A
• Parekh, P I
• Rosinsky, N
• Ring, H A
• Pazzaglia, P J
• Marangell, L B
• Callahan, A M
• Post, R M

Titel

Blunted left cingulate activation in mood disorder subjects during a response interference task (the Stroop)

Ist Teil von

• The journal of neuropsychiatry and clinical neurosciences, 1997-02, Vol.9 (1), p.55-63

Ort / Verlag

United States: American Psychiatric Publishing

Erscheinungsjahr

1997

Quelle

MEDLINE

Beschreibungen/Notizen

• Functional neuroimaging studies have found abnormal anterior cingulate activity in depressed subjects, and other studies have shown that the cingulate gyrus becomes active in healthy subjects during interference tasks. The authors hypothesized that subjects with mood disorder might show blunted cingulate activation during the standard Stroop interference task or during a modified version involving sadness-laden words. In contrast to 11 age- and sex-matched healthy control subjects who activated the left cingulate during the standard Stroop, 11 mood- disordered subjects activated the right anterior cingulate gyrus only slightly and instead showed increased activity in the left dorsolateral prefrontal and visual cortex. This study supports theories of blunted limbic and paralimbic activation and abnormal cingulate activity in depression and adds to the growing knowledge of the functional neuroanatomy of depression.