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Local-circuit neurones in the medial prefrontal cortex (areas 25, 32 and 24b) in the rat: Morphology and quantitative distribution
Journal of comparative neurology (1911), 1997-01, Vol.377 (4), p.465-499
Gabbott, Paul L.A.
Dickie, Brian G.M.
Vaid, R. Roy
Headlam, Anthony J.N.
Bacon, Sarah J.
1997
Details
Autor(en) / Beteiligte
Gabbott, Paul L.A.
Dickie, Brian G.M.
Vaid, R. Roy
Headlam, Anthony J.N.
Bacon, Sarah J.
Titel
Local-circuit neurones in the medial prefrontal cortex (areas 25, 32 and 24b) in the rat: Morphology and quantitative distribution
Ist Teil von
Journal of comparative neurology (1911), 1997-01, Vol.377 (4), p.465-499
Ort / Verlag
New York: John Wiley & Sons, Inc
Erscheinungsjahr
1997
Link zum Volltext
Quelle
Wiley-Blackwell Journals
Beschreibungen/Notizen
This paper is a light microscopical study describing the detailed morphology and quantitative distribution of local circuit neurones in areas 25, 32, and 24b of the medial prefrontal cortex (mPFC) in the rat. Cortical interneurones were identified immunocytochemically by their expression of calretinin (CR), parvalbumin (PV), and calbindin D‐28k (CB) immunoreactivity. Neurones immunoreactive for γ‐aminobutyric acid (GABA) were also investigated, as were interneurones containing reduced nicotinamide adenine dinucleotide phosphate (NADPH) diaphorase activity. Several distinct classes of CR+, PV+, and CB+ neurones were identified; the most frequent were: bipolar/bitufted CR+ cells in upper layer 3; multipolar PV+ neurones in layers 3 and 5; and bitufted/multipolar CB+ neurones in lower layer 3. CB+ neurones resembling Martinotti and neurogliaform cells were also present in layers 5/6. The morphologies and depth distributions of each cell type were consistent across the three areas of mPFC studied. Seven classes of diaphorase‐reactive mPFC neurone are described; these cells were composed about 0.8% of the total neurone population and had a peak distribution located in mid‐ to lower layer 5 in each area. In areas 32 and 25, three defined bands of diffuse NADPH diaphorase staining were located in layer 2 and in upper and deep layer 5. Diaphorase reactivity was very infrequently colocalised with either CR, PV, or CB immunoreactivities. The numerical densities of neurones (NV, number of cells per mm3) in each layer were calculated stereologically. The mean total neuronal NV estimate for areas 25, 32, and 24b was 51,603 ± 3,324 (mean ± S.D.; n = 8). Significant interareal differences were detected. From cortical thickness data and neuronal NV estimates, the absolute number of neurones under 1 mm2 of cortical surface (NC) have been derived. The mean NC value for areas 25, 32, and 24b was 57,328 ± 7,505 neurones. In immunolabelled Nissl‐stained sections, CR+ neurones constituted an overall 4.0%, PV+ cells 5.6%, and CB+ 3.4% of the total neurone populations in mPFC. GABA+ cells represented a mean of 16.2% (14.8–17.2%) of neurones in areas 25, 32 and 24b. The absolute numbers of CR+, PV+, CB+, and GABA+ neurones within individual layers in a column of cortex under 1 mm2 of cortical surface (NL) have also been derived, with significant interareal differences in NL values being detected. The data provide the structural basis for a qualitative and quantitative definition of local cortical circuits in the rat mPFC. J. Comp. Neurol. 377:465–499, 1997. © 1997 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0021-9967
eISSN: 1096-9861
DOI: 10.1002/(SICI)1096-9861(19970127)377:4<465::AID-CNE1>3.0.CO;2-0
Titel-ID: cdi_proquest_miscellaneous_78805631
Format
–
Schlagworte
Animals
,
Calbindin 2
,
Calbindins
,
calcium-binding proteins
,
Calcium-Binding Proteins - analysis
,
Cell Count
,
Cell Size
,
cortical modules
,
Dendrites - ultrastructure
,
Female
,
GABA
,
gamma-Aminobutyric Acid - analysis
,
Immunoenzyme Techniques
,
limbic system
,
Male
,
NADPH Dehydrogenase - analysis
,
NADPH diaphorase
,
Nerve Tissue Proteins - analysis
,
Neurons - ultrastructure
,
Parvalbumins - analysis
,
Prefrontal Cortex - cytology
,
Rats
,
Rats, Sprague-Dawley
,
S100 Calcium Binding Protein G - analysis
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