Details

Autor(en) / Beteiligte

• Manca, Fabrizio
• Fenoglio, Daniela
• Kunkl, Annalisa
• Cambiaggi, Caterina
• Li Pira, Giuseppina
• Celada, Franco

Titel

B cells on the podium: regulatory roles of surface and secreted immunoglobulins

Ist Teil von

• Immunology today (Amsterdam. Regular ed.), 1988, Vol.9 (10), p.300-303

Ort / Verlag

England: Elsevier B.V

Erscheinungsjahr

1988

Quelle

Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)

Beschreibungen/Notizen

• A long-lasting prejudice in immunology pictures T cells as active regulatory subjects and B cells as passively regulated objects. In this article, Fabrizio Manca and colleagues discuss how the notion of a passive, regulated B cell is being superseded. The emerging hypothesis is that B lymphocytes not only capture, internalize, process and present antigens to T cells, they also - through their specific paratope — govern the patterns of enzymatic degradation, and thus are instrumental in selecting the particular T cell from which they gain help. B cells therefore influence the expression of both T- and B-cell repertoires.