Immunology letters, 1988-12, Vol.19 (4), p.313-320
1988
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Details
- Autor(en) / Beteiligte
- Titel
- Pinocchio cells: morphologically atypical immunologically heterogeneous lymphocytes induced by treatment with interleukin 2
- Ist Teil von
- Immunology letters, 1988-12, Vol.19 (4), p.313-320
- Ort / Verlag
- Netherlands: Elsevier B.V
- Erscheinungsjahr
- 1988
- Quelle
- Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)
- Beschreibungen/Notizen
- We describe a novel cell type, the Pinocchio cell, that appears in the peripheral blood of all patients receiving treatment with interleukin 2, up to 20000 cells/μl. This cell is characterized by a prominent and granular proboscis with which it attaches to tumor cells and mediates tumor cell lysis. Pinocchio cells are immunologically heterogeneous and express antigens of both T and NK cells; Pinocchio cells are adherent in culture and are more cytolytic than non-adherent cells against NK-sensitive and resistant tumor cells. Incubation of normal whole human blood for 1 h induces Pinocchio morphology of mononuclear white blood cells.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0165-2478eISSN: 1879-0542DOI: 10.1016/0165-2478(88)90161-7Titel-ID: cdi_proquest_miscellaneous_78727663
- Format
- –
- Schlagworte
- Antigens, Differentiation, Cell Adhesion, Cell Movement, Cytotoxicity, Immunologic, Humans, Immunotherapy, In Vitro Techniques, Interleukin 2, Interleukin-2 - pharmacology, Killer Cells, Natural - immunology, Killer Cells, Natural - pathology, Lymphocyte, Lymphocytes - immunology, Lymphocytes - pathology, Lymphocytes - physiology, Neoplasms - blood, Neoplasms - immunology, Neoplasms - therapy, Pinocchio cells, T-Lymphocytes - immunology, T-Lymphocytes - pathology