Details

Autor(en) / Beteiligte

• KITAMURA, KIYOSHI
• MIYAGAWA, KIYOSHI
• URABE, AKIO
• SATO, HIROSHI
• OBAYASHI, YOSHIAKI
• AOKI, ISAO
• TAKAKU, FUMIMARO
• TOGAWA, ATSUSHI
• SHINDOU, EIICHI
• WAKABAYASHI, YOSHIHISA
• OHSHIMA, TOSHITERU
• HORIKOSHI, AKIRA
• NOMURA, TAKEO
• OHKI, ICHIRO
• SUZUKI, KENSHI
• KAMAKURA, MASAHIDE
• OGUCHI, ATSUSHI
• TOYAMA, KEISUKE
• YAGUCHI, MAKOTO
• AOKI, NOBUO
• KATO, ATSUSHI
• MIZOGUCHI, HIDEAKI
• MASUDA, MICHIHIKO
• IRIE, SEIJI
• MORI, MAYUMI
• KUMAKAWA, TOSHIRO
• MUTO, YOSHITOMO
• MORINAGA, SHINICHI
• FUJIOKA, SEITOKU

Titel

CLINICAL STUDY ON A CONCOMITANT THERAPY WITH FLUCONAZOLE AND HUMAN RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR IN THE TREATMENT OF SYSTEMIC FUNGAL INFECTIONS WITH HEMATOLOGICAL DISORDERS

Ist Teil von

• The Japanese Journal of Antibiotics, 1996/12/25, Vol.49(12), pp.1062-1072

Ort / Verlag

Japan: Japan Antibiotics Research Association

Erscheinungsjahr

1996

Quelle

MEDLINE

Beschreibungen/Notizen

• The clinical efficacy and the safety of concomitant therapy with fluconazole and recombinant human granulocyte colony stimulating factor (rhG-CSF) was compared with fluconazole monotherapy in neutropenic patients with hematological disorders. The clinical efficacy rate was 73.5% (25/34) in the combination therapy and 48.1% (37/77) in monotherapy. The difference between the two is statistically significant. Side effects were not observed in the combination group, but laboratory abnormalities were found in 6 patients with an incident rate of 11%. The combination therapy with fluconazole and rhG-CSF may be selected as empiric therapy for systemic fungal infection associated with hematological disorders, since this combination therapy showed high efficacy and low incident of side effects. Some patients, however, did not show increased neutrophil counts in spite of rhG-CSF administration.