Details

Autor(en) / Beteiligte

• Giometto, Bruno
• Miotto, Deborah
• Faresin, Florio
• Argentiero, Vincenza
• Scaravilli, Tomaso
• Tavolato, Bruno

Titel

Anti-gabaergic neuron autoantibodies in a patient with stiff-man syndrome and ataxia

Ist Teil von

• Journal of the neurological sciences, 1996-11, Vol.143 (1), p.57-59

Ort / Verlag

Netherlands: Elsevier B.V

Erscheinungsjahr

1996

Quelle

Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)

Beschreibungen/Notizen

• We describe a patient with autoimmune insulin-dependent diabetes whose original symptoms of trunk stiffness and rigidity of the abdomen were followed three years later by a pancerebellar syndrome. An autoantibody (autoAb) against GABAergic neurons was found in the patient's serum and cerebrospinal fluid (CSF); on Western blot, this autoAb recognized a 64-kDa antigen of cerebellar protein. The detection of this antibody in a case with ataxia suggests that a spectrum of different neurological diseases may be observed in patients harbouring anti-GABAergic neuron autoAb and supports the concept that factors other than autoAb contribute to the clinical presentation of these disorders.