Details

Autor(en) / Beteiligte

• Newport, Melanie J
• Huxley, Clare M
• Huston, Sara
• Hawrylowicz, Catherine M
• Oostra, Ben A
• Williamson, Robert
• Levin, Michael

Titel

A Mutation in the Interferon-γ –Receptor Gene and Susceptibility to Mycobacterial Infection

Ist Teil von

• The New England journal of medicine, 1996-12, Vol.335 (26), p.1941-1949

Ort / Verlag

Boston, MA: Massachusetts Medical Society

Erscheinungsjahr

1996

Quelle

MEDLINE

Beschreibungen/Notizen

• The World Health Organization has estimated that more than 1.7 billion persons are infected with Mycobacterium tuberculosis worldwide. 1 , 2 A puzzling feature of mycobacterial infection is that clinically evident disease occurs in only a small proportion of those who are infected. However, the mechanisms that distinguish a successful immune response, which contains the infection, from an ineffective response, which enables progressive disease to occur, remain poorly understood. Familial clustering, racial differences in incidence, and twin studies suggest that genetic factors have a role in susceptibility. 3 – 5 However, in contrast to the situation in mice, in which a number of single . . .