Details

Autor(en) / Beteiligte

• KOIZUMI, FUMIAKI
• KAWAMURA, TAKESHI
• ISHIMORI, AKIRA
• EBINA, HIROKO
• SATOH, MICHINORI

Titel

Plasma Paracetamol Concentrations Measured by Fluorescence Polarization Immunoassay and Gastric Emptying Time

Ist Teil von

• The Tohoku Journal of Experimental Medicine, 1988, Vol.155(2), pp.159-164

Ort / Verlag

Japan: Tohoku University Medical Press

Erscheinungsjahr

1988

Link zum Volltext

Quelle

Elektronische Zeitschriftenbibliothek (Open access)

Beschreibungen/Notizen

• KOIZUMI, F., KAWAMURA, T., ISHIMORI, A., EBINA, H. and SATOH, M. Plasma Paracetamol Concentrations Measured by Fluorescence Polarization Immunoassay and Gastric Emptying Time. Tohoku J. exp. Med., 1988, 155 (2), 159-164 -Radionuclide labeled gastric emptying was compared with plasma paracetamol (acetaminophen) concentration measured by fluorescence polarization immunoassay. A significant correlation was found between both gastric emptying half-time of radionuclide (t1/2) and % isotope remained in the region of the stomach and paracetamol absorption kinetic parameters. The strongest correlation was found between t1/2 and the time required to reach the peak plasma level of paracetamol (r=0.680, p<0.01). This study indicates that simple paracetamol marker method has enabled an indirect quantitative measurement of gastric emptying by sampling at varying time intervals.