Details

Autor(en) / Beteiligte

• Peines, M.A.
• Sarciron, E.
• Audin, P.
• Mojon, M.
• Petavy, A.F.
• Gabrion, C.

Titel

The effect of isatin on the Echinococcus granulosus cyst in an experimental host

Ist Teil von

• Veterinary parasitology, 1988-11, Vol.30 (1), p.31-44

Ort / Verlag

Netherlands: Elsevier B.V

Erscheinungsjahr

1988

Link zum Volltext

Quelle

Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)

Beschreibungen/Notizen

• The effect of isatin on the E. granulosus cyst was studied. NMRI mice, which were infected with E. granulosus of sheep origin, were treated daily with isatin at a dose of 50 mg kg −1 for 18 days. Ultrastructural damage was observed in the treated cysts, including accumulation of lamellar stacks, electron-dense granules, autophagosomes and lipid vesicles. Moreover, a biochemical study showed an inhibition of alkaline phosphatase activity, with a decrease in carbohydrate storage and an increase in acid phophatase activity. In spite of the short durationof the treatment, the results obtained allowd us to conclude that isatin acts on E. granulosus cysts. This activity appears as a process of degeneration linked to the alkaline phosphatase inhibitory effect of isatin.