Details

Autor(en) / Beteiligte

• Kapur, Ravi
• Spargo, Barry J.
• Chen, Mu-San
• Calvert, Jeffrey M.
• Rudolph, Alan S.

Titel

Fabrication and selective surface modification of 3-dimensionally textured biomedical polymers from etched silicon substrates

Ist Teil von

• Journal of biomedical materials research, 1996, Vol.33 (4), p.205-216

Ort / Verlag

New York: John Wiley & Sons, Inc

Erscheinungsjahr

1996

Quelle

Wiley-Blackwell Full Collection

Beschreibungen/Notizen

• A new method is described for producing biomedically relevant polymers with precisely defined micron scale surface texture in the x, y, and z planes. Patterned Si templates were fabricated using photolithography to create a relief pattern in photoresist with lateral dimensions as small as I μm. Electroless Ni was selectively deposited in the trenches of the patterned substrate. The Ni served as a resilient mask for transferring the patterns onto the Si substrate to depths of up to 8.5 μm by anisotropic reactive ion etching with a fluorine‐based plasma. The 3‐dimensional (3‐D) textured silicon substrates were used as robust, reusable molds for pattern transfer onto poly(dimethyl siloxane), low density poly(ethylene), poly(L‐lactide), and poly(glycolide) by either casting or injection molding. The fidelity of the pattern transfer from the silicon substrates to the polymers was 90 to 95% in all three planes for all polymers for more than 60 transfers from a single wafer, as determined by scanning electron microscopy and atomic force microscopy. Further, the 3‐D textured polymers were selectively modified to coat proteins either in the trenches or on the mesas by capillary modification or selective coating techniques. These selectively patterned 3‐D polymer substrates may be useful for a variety of biomaterial applications. © 1996 John Wiley & Sons, Inc.