Details

Autor(en) / Beteiligte

• Chau, Tran Thi Hong
• Day, Nicholas P. J.
• Van Chuong, Ly
• Mai, Nguyen Thi Hoang
• Loc, Pham Phu
• Phu, Nguyen Hoan
• Bethell, Delia B.
• Sinh, Dinh Xuan
• Hien, Tran Tinh
• White, Nicholas J.

Titel

Blackwater Fever in Southern Vietnam: A Prospective Descriptive Study of 50 Cases

Ist Teil von

• Clinical infectious diseases, 1996-12, Vol.23 (6), p.1274-1281

Ort / Verlag

Chicago, IL: The University of Chicago Press

Erscheinungsjahr

1996

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• We prospectively studied 50 Vietnamese patients with blackwater fever (BWF). All patients had fever and hemoglobinuria, 40 (80%) were jaundiced, 25 (50%) had hepatomegaly, 17 (34%) had splenomegaly, and 9 (18%) had hepatosplenomegaly. Twenty-one patients (42%) had impaired renal function, with creatinine clearances of <50 mL/min/m2; however, only four (8%) developed oliguric renal failure, three (6%) of whom required dialysis. Forty-four patients (88%) developed anemia, which was severe (hematocrit, <20%) in 32 (64%). One patient died, representing a death rate for this once-feared disease that is considerably lower than that reported by earlier investigators. BWF was associated with quinine ingestion in 28 patients (56%), glucose-6-phosphate dehydrogenase (G6PD) deficiency in 27 (54%), and concurrent malaria infection in 16 (32%). There was no statistically significant difference in the severity of BWF associated with each of these three factors, as assessed by creatinine clearance and the hematocrit value on admission and by the number of units of blood transfused. There was considerable overlap in the occurrence of G6PD deficiency, quinine ingestion, and malaria, suggesting that these factors may interact and that it may not be justifiable to regard hemoglobinuria caused by G6PD deficiency as a separate syndrome.