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Multiple Extracellular Elements of CCR5 and HIV-1 Entry: Dissociation from Response to Chemokines
Science (American Association for the Advancement of Science), 1996-12, Vol.274 (5294), p.1924-1926
1996

Details

Autor(en) / Beteiligte
Titel
Multiple Extracellular Elements of CCR5 and HIV-1 Entry: Dissociation from Response to Chemokines
Ist Teil von
  • Science (American Association for the Advancement of Science), 1996-12, Vol.274 (5294), p.1924-1926
Ort / Verlag
Washington, DC: American Society for the Advancement of Science
Erscheinungsjahr
1996
Link zum Volltext
Quelle
American Association for the Advancement of Science
Beschreibungen/Notizen
  • The human β-chemokine receptor CCR5 is an important cofactor for entry of human immunodeficiency virus-type 1 (HIV-1). The murine form of CCR5, despite its 82 percent identity to the human form, was not functional as an HIV-1 coreceptor. HIV-1 entry function could be reconstituted by fusion of various individual elements derived from the extracellular region of human CCR5 onto murine CCR5. Analysis of chimeras containing elements from human CCR5 and human CCR2B suggested that a complex structure rather than single contact sites is responsible for facilitation of viral entry. Further, certain chimeras lacking the domains necessary to signal in response to their natural chemokine ligands retained vigorous HIV-1 coreceptor activity.
Sprache
Englisch
Identifikatoren
ISSN: 0036-8075
eISSN: 1095-9203
DOI: 10.1126/science.274.5294.1924
Titel-ID: cdi_proquest_miscellaneous_78581533
Format
–
Schlagworte
AIDS/HIV, Animals, Biological and medical sciences, CD4 Antigens - metabolism, Chemokine receptors, Chemokines, Chimeras, COS Cells, Fundamental and applied biological sciences. Psychology, HIV, HIV 1, HIV-1 - metabolism, Human immunodeficiency virus, human immunodeficiency virus 1, Humans, Inositol Phosphates - metabolism, Ligands, Medical immunity, Medical research, Mice, Microbiology, Plasmids, Receptors, Receptors, CCR2, Receptors, CCR5, Receptors, Chemokine, Receptors, Cytokine - chemistry, Receptors, Cytokine - genetics, Receptors, Cytokine - metabolism, Receptors, HIV - chemistry, Receptors, HIV - genetics, Receptors, HIV - metabolism, Recombinant Fusion Proteins - metabolism, Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains, Signal Transduction, Transfection, Virology, Viruses

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