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Evidence for a novel regulatory pathway activated by (carba)prostacyclin in preadipose and adipose cells
Ist Teil von
FEBS letters, 1996-11, Vol.397 (1), p.117-121
Ort / Verlag
England: Elsevier B.V
Erscheinungsjahr
1996
Quelle
Wiley Online Library - AutoHoldings Journals
Beschreibungen/Notizen
Prostacyclin, one of the major prostanoids generated in adipose tissue, has been previously described as an autocrine/ paracrine adipogenic effector, acting, in preadipose cells, by means of cAMP and free Ca
2+ as cell surface receptor-mediated messengers. The present study presents evidence for the first time that its stable analogue, carbaprostacyclin, is unique among prostanoids in regulating the expression of two differentiation-dependent genes in preadipose and adipose cells in a way distinct from that elicited by its cell surface receptor. This regulation is likely mediated by some member(s) of the peroxisome proliferator-activated receptor family and suggests that prostacyclin behaves as an intracrine effector of adipose cell differentiation.