FEBS letters, 1996-11, Vol.397 (1), p.117-121
1996
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Details
- Autor(en) / Beteiligte
- Titel
- Evidence for a novel regulatory pathway activated by (carba)prostacyclin in preadipose and adipose cells
- Ist Teil von
- FEBS letters, 1996-11, Vol.397 (1), p.117-121
- Ort / Verlag
- England: Elsevier B.V
- Erscheinungsjahr
- 1996
- Quelle
- Wiley Online Library - AutoHoldings Journals
- Beschreibungen/Notizen
- Prostacyclin, one of the major prostanoids generated in adipose tissue, has been previously described as an autocrine/ paracrine adipogenic effector, acting, in preadipose cells, by means of cAMP and free Ca 2+ as cell surface receptor-mediated messengers. The present study presents evidence for the first time that its stable analogue, carbaprostacyclin, is unique among prostanoids in regulating the expression of two differentiation-dependent genes in preadipose and adipose cells in a way distinct from that elicited by its cell surface receptor. This regulation is likely mediated by some member(s) of the peroxisome proliferator-activated receptor family and suggests that prostacyclin behaves as an intracrine effector of adipose cell differentiation.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0014-5793eISSN: 1873-3468DOI: 10.1016/S0014-5793(96)01152-0Titel-ID: cdi_proquest_miscellaneous_78581140
- Format
- –
- Schlagworte
- 3T3 Cells, Adipocytes - cytology, Adipocytes - drug effects, Adipocytes - metabolism, Adipose tissue, Angiotensinogen, Angiotensinogen - biosynthesis, Angiotensinogen - genetics, Animals, Carrier Proteins - biosynthesis, Carrier Proteins - genetics, Cell Differentiation, Cell Line, Dexamethasone - pharmacology, Dose-Response Relationship, Drug, Epoprostenol - analogs & derivatives, Epoprostenol - pharmacology, Fatty acid binding protein, Fatty Acid-Binding Protein 7, Fatty Acid-Binding Proteins, Gene Expression Regulation - drug effects, Hormone Antagonists - pharmacology, Mice, Mifepristone - pharmacology, Myelin P2 Protein - biosynthesis, Myelin P2 Protein - genetics, Neoplasm Proteins, Nerve Tissue Proteins, Peroxisome proliferator activated receptor, Prostacyclin, Prostaglandins - pharmacology, Prostanoid, Receptors, Epoprostenol, Receptors, Prostaglandin - metabolism, RNA, Messenger - genetics, RNA, Messenger - metabolism