Details

Autor(en) / Beteiligte

• Bertinchant, Jean-Pierre
• Larue, Catherine
• Pernel, Isabelle
• Ledermann, Bertrand
• Fabbro-Peray, Pascale
• Beck, Lionel
• Calzolari, Charles
• Trinquier, Sylvie
• Nigond, Jacques
• Pau, Bernard

Titel

Release kinetics of serum cardiac troponin i in ischemic myocardial injury

Ist Teil von

• Clinical biochemistry, 1996-12, Vol.29 (6), p.587-594

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

1996

Quelle

Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)

Beschreibungen/Notizen

• Objectives: The study was undertaken to evaluate the release kinetics of cardiac troponin I (c-cTn-I) in ischemic myocardial injury. Design and Methods: The reference range for cTn-I was established by determination of cTn-I in sera and plasma obtained from 622 healthy volunteers (Group 1). cTn-I was compared to: (a) Creatine kinase (CK) MB mass and myoglobin in 12 patients with severe skeletal muscle damage (Group 2); (b) CK-MB activity in 48 patients with myocardial infarction (MI) receiving intravenous thrombolysis (Group 3) (in this group, an additional 43 patients with MI were analyzed separately to characterize cTn-I patterns in thrombolyzed and nonthrombolyzed populations); and in 44 patients with unstable angina (Group 4). Results: In Groups 1 and 2, no positive results (⩾0.1 μg/L) were obtained. In Group 3, the time-courses of cTn-I were mostly monophasic in form. A pathologic increase occurred earlier in cTn-I than in CK-MB activity ( p = 0.0002); the period with increased cTn-I was longer ( p = 0.001), the overall sensitivity of cTn-I (93.9%) was higher than that of CK-MB activity ( p = 0.00001). cTn-I was more sensitive at admission ( p = 0.0004). In additional patients, the cTn-I peak occurred and cTn-I disappeared significantly later in nonthrombolyzed than in the thrombolyzed group. In Group 4, positive tests results were detected in 45% of patients for cTn-I, 16% for CK-MB activity, and 32% for CK-MB mass. Conclusions: The cTn-I assay appears to be ideally suited for the detection of ischemic myocardial injury in complex clinical situations because of its high specificity; cTn-I indicates myocardial tissue damage in patients with unstable angina and is superior to CK-MB activity and mass in this respect.