Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...
Zur Ergebnisliste
Ergebnis 6 von 9
    Datensatz exportieren als...
  • BibTeX
Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein
Science (American Association for the Advancement of Science), 1996-11, Vol.274 (5291), p.1377-1379
1996

Details

Autor(en) / Beteiligte
Titel
Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein
Ist Teil von
  • Science (American Association for the Advancement of Science), 1996-11, Vol.274 (5291), p.1377-1379
Ort / Verlag
Washington, DC: American Society for the Advancement of Science
Erscheinungsjahr
1996
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
  • Fatty acid binding proteins (FABPs) are small cytoplasmic proteins that are expressed in a highly tissue-specific manner and bind to fatty acids such as oleic and retinoic acid. Mice with a null mutation in aP2, the gene encoding the adipocyte FABP, were developmentally and metabolically normal. The aP2-deficient mice developed dietary obesity but, unlike control mice, they did not develop insulin resistance or diabetes. Also unlike their obese wild-type counterparts, obese aP2-/- animals failed to express in adipose tissue tumor necrosis factor-alpha (TNF-alpha), a molecule implicated in obesity-related insulin resistance. These results indicate that aP2 is central to the pathway that links obesity to insulin resistance, possibly by linking fatty acid metabolism to expression of TNF-alpha
Sprache
Englisch
Identifikatoren
ISSN: 0036-8075
eISSN: 1095-9203
DOI: 10.1126/science.274.5291.1377
Titel-ID: cdi_proquest_miscellaneous_78521210
Format
–
Schlagworte
Adipocytes, Adipose Tissue - metabolism, Adipose tissues, Animals, Biological and medical sciences, Blood Glucose - metabolism, Carrier proteins, Carrier Proteins - genetics, Carrier Proteins - metabolism, Carrier Proteins - physiology, Classical genetics, quantitative genetics, hybrids, Diabetes, Dietary Fats - administration & dosage, Fat cells, Fatty Acid-Binding Protein 7, Fatty Acid-Binding Proteins, Fatty acids, Fatty Acids - metabolism, Female, Fundamental and applied biological sciences. Psychology, Gene Expression Regulation, Gene Targeting, Genetics of eukaryotes. Biological and molecular evolution, Glucose Tolerance Test, Homeostasis, Insulin, Insulin - blood, Insulin Resistance, Male, Messenger RNA, Mice, Mice, Inbred C57BL, MUTACION, MUTATION, Myelin P2 Protein - genetics, Myelin P2 Protein - metabolism, Myelin P2 Protein - physiology, Neoplasm Proteins, Nerve Tissue Proteins, Obesity, Obesity - metabolism, PROTEINAS AGLUTINANTES, PROTEINE DE LIAISON, Proteins, RATON, Rodents, SOBREPESO, SOURIS, SURPOIDS, Transport proteins, TRASTORNOS METABOLICOS, Triglycerides - blood, TROUBLE DU METABOLISME, Tumor Necrosis Factor-alpha - biosynthesis, Tumor Necrosis Factor-alpha - genetics, Type 2 diabetes mellitus, Vertebrata

Weiterführende Literatur

Empfehlungen zum selben Thema automatisch vorgeschlagen von bX