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Association of Integrase, Matrix, and Reverse Transcriptase Antigens of Human Immunodeficiency Virus Type 1 with Viral Nucleic Acids Following Acute Infection

Proceedings of the National Academy of Sciences - PNAS, 1993-07, Vol.90 (13), p.6125-6129

1993

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A Mutation in Reverse Transcriptase of Bis(heteroaryl)Piperazine-Resistant Human Immunodeficiency Virus Type 1 that Confers Increased Sensitivity to Other Nonnucleoside Inhibitors

Proceedings of the National Academy of Sciences - PNAS, 1993-05, Vol.90 (10), p.4713-4717

1993

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Novel 1,5-Diphenylpyrazole Nonnucleoside HIV-1 Reverse Transcriptase Inhibitors with Enhanced Activity versus the Delavirdine-Resistant P236L Mutant: Lead Identification and SAR of 3- and 4-Substituted Derivatives

Journal of medicinal chemistry, 2000-03, Vol.43 (5), p.1034-1040

2000

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A Drug Resistance Mutation in the Inhibitor Binding Pocket of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Impairs DNA Synthesis and RNA Degradation

Biochemistry (Easton), 1996-07, Vol.35 (30), p.9737-9745

1996

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A recombinant ribonuclease H domain of HIV-1 reverse transcriptase that is enzymatically active

The Journal of biological chemistry, 1991-11, Vol.266 (31), p.20583-20585

1991

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Functional characterization of RNA-dependent DNA polymerase and RNase H activities of a recombinant HIV reverse transcriptase

Biochemistry (Easton), 1991-03, Vol.30 (10), p.2651-2655

1991

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Oxazolidinones: a new class of antibacterials

Current Opinion in Pharmacology, 2001-10, Vol.1 (5), p.470-476

2001

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Steady-state kinetic studies with the non-nucleoside HIV-1 reverse transcriptase inhibitor U-87201E

The Journal of biological chemistry, 1993-03, Vol.268 (9), p.6119-6124

1993

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An Inhibitor of the Protease Blocks Maturation of Human and Simian Immunodeficiency Viruses and Spread of Infection

Proceedings of the National Academy of Sciences - PNAS, 1990-10, Vol.87 (19), p.7472-7476

1990

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Pyrimidine Thioethers: A Novel Class of HIV-1 Reverse Transcriptase Inhibitors with Activity Against BHAP-Resistant HIV

Journal of medicinal chemistry, 1998-09, Vol.41 (20), p.3793-3803

1998

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Treatment of human immunodeficiency virus type 1 (HIV-1)-infected cells with combinations of HIV-1-specific inhibitors results in a different resistance pattern than does treatment with single-drug therapy

Journal of Virology, 1993-09, Vol.67 (9), p.5353-5359

1993

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The quinoline U-78036 is a potent inhibitor of HIV-1 reverse transcriptase

The Journal of biological chemistry, 1993-07, Vol.268 (20), p.14875-14880

1993

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The benzylthio-pyrimidine U-31,355, a potent inhibitor of HIV-1 reverse transcriptase

Biochemical pharmacology, 1996-03, Vol.51 (6), p.743-750

1996

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Kinetic studies with the non-nucleoside HIV-1 reverse transcriptase inhibitor U-88204E

Biochemistry (Easton), 1993-07, Vol.32 (26), p.6548-6554

1993

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Targeting Delavirdine/Atevirdine Resistant HIV-1: Identification of (Alkylamino)piperidine-Containing Bis(heteroaryl)piperazines as Broad Spectrum HIV-1 Reverse Transcriptase Inhibitors

Journal of medicinal chemistry, 1996-09, Vol.39 (19), p.3769-3789

1996

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Kinetic studies with the non-nucleoside human immunodeficiency virus type-1 reverse transcriptase inhibitor U-90152E

Biochemical pharmacology, 1994-06, Vol.47 (11), p.2017-2028

1994

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The binding of a novel bisheteroarylpiperazine mediates inhibition of human immunodeficiency virus type 1 reverse transcriptase

The Journal of biological chemistry, 1992-01, Vol.267 (1), p.27-30

1992

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(Alkylamino) piperidine bis(heteroaryl)piperizine analogs are potent, broad-spectrum nonnucleoside reverse transcriptase inhibitors of drug-resistant isolates of human immunodeficiency virus type 1 (HIV-1) and select for drug-resistant variants of HIV-1IIIB with reduced replication phenotypes

Journal of Virology, 1996-06, Vol.70 (6), p.3698-3705

1996

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Loss of Platelet-Derived Growth Factor-Stimulated Phospholipase Activity in NIH-3T3 Cells Expressing the EJ-ras Oncogene

Proceedings of the National Academy of Sciences - PNAS, 1987-01, Vol.84 (2), p.546-550

1987

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Inhibitors of the protease from human immunodeficiency virus: design and modeling of a compound containing a dihydroxyethylene isostere insert with high binding affinity and effective antiviral activity

Journal of medicinal chemistry, 1991-08, Vol.34 (8), p.2344-2356

1991

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Inhibition of the protease of human immunodeficiency virus blocks replication and infectivity of the virus in chronically infected macrophages

The Journal of infectious diseases, 1993-11, Vol.168 (5), p.1148

1993

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Characterization of the p68/p58 Heterodimer of Human Immunodeficiency Virus Type 2 Reverse Transcriptase

Biochemistry (Easton), 1996-02, Vol.35 (6), p.1911-1917

1996

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The Differential Processing of Homodimers of Reverse Transcriptases from Human Immunodeficiency Viruses Type 1 and 2 Is a Consequence of the Distinct Specificities of the Viral Proteases

The Journal of biological chemistry, 1995-06, Vol.270 (22), p.13573-13579

1995

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Mechanism of resistance to U-90152S and sensitization to L-697,661 by a proline to leucine change at residue 236 of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase

FEBS letters, 1995-02, Vol.359 (2), p.233-238

1995

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Association of Integrase, Matrix, and Reverse Transcriptase Antigens of Human Immunodeficiency Virus Type 1 with Viral Nucleic Acids Following Acute Infection

A Mutation in Reverse Transcriptase of Bis(heteroaryl)Piperazine-Resistant Human Immunodeficiency Virus Type 1 that Confers Increased Sensitivity to Other Nonnucleoside Inhibitors

Novel 1,5-Diphenylpyrazole Nonnucleoside HIV-1 Reverse Transcriptase Inhibitors with Enhanced Activity versus the Delavirdine-Resistant P236L Mutant: Lead Identification and SAR of 3- and 4-Substituted Derivatives

A Drug Resistance Mutation in the Inhibitor Binding Pocket of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Impairs DNA Synthesis and RNA Degradation

A recombinant ribonuclease H domain of HIV-1 reverse transcriptase that is enzymatically active

Functional characterization of RNA-dependent DNA polymerase and RNase H activities of a recombinant HIV reverse transcriptase

Oxazolidinones: a new class of antibacterials

(−)-6-Chloro-2-[(1-furo[2,3-c]pyridin-5-ylethyl)thio]-4-pyrimidinamine, PNU-142721, a New Broad Spectrum HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitor

Steady-state kinetic studies with the non-nucleoside HIV-1 reverse transcriptase inhibitor U-87201E

An Inhibitor of the Protease Blocks Maturation of Human and Simian Immunodeficiency Viruses and Spread of Infection

Pyrimidine Thioethers: A Novel Class of HIV-1 Reverse Transcriptase Inhibitors with Activity Against BHAP-Resistant HIV

Treatment of human immunodeficiency virus type 1 (HIV-1)-infected cells with combinations of HIV-1-specific inhibitors results in a different resistance pattern than does treatment with single-drug therapy

The quinoline U-78036 is a potent inhibitor of HIV-1 reverse transcriptase

The benzylthio-pyrimidine U-31,355, a potent inhibitor of HIV-1 reverse transcriptase

Kinetic studies with the non-nucleoside HIV-1 reverse transcriptase inhibitor U-88204E

Targeting Delavirdine/Atevirdine Resistant HIV-1: Identification of (Alkylamino)piperidine-Containing Bis(heteroaryl)piperazines as Broad Spectrum HIV-1 Reverse Transcriptase Inhibitors

Kinetic studies with the non-nucleoside human immunodeficiency virus type-1 reverse transcriptase inhibitor U-90152E

The binding of a novel bisheteroarylpiperazine mediates inhibition of human immunodeficiency virus type 1 reverse transcriptase

(Alkylamino) piperidine bis(heteroaryl)piperizine analogs are potent, broad-spectrum nonnucleoside reverse transcriptase inhibitors of drug-resistant isolates of human immunodeficiency virus type 1 (HIV-1) and select for drug-resistant variants of HIV-1IIIB with reduced replication phenotypes

Loss of Platelet-Derived Growth Factor-Stimulated Phospholipase Activity in NIH-3T3 Cells Expressing the EJ-ras Oncogene

Inhibitors of the protease from human immunodeficiency virus: design and modeling of a compound containing a dihydroxyethylene isostere insert with high binding affinity and effective antiviral activity

Inhibition of the protease of human immunodeficiency virus blocks replication and infectivity of the virus in chronically infected macrophages

Characterization of the p68/p58 Heterodimer of Human Immunodeficiency Virus Type 2 Reverse Transcriptase

The Differential Processing of Homodimers of Reverse Transcriptases from Human Immunodeficiency Viruses Type 1 and 2 Is a Consequence of the Distinct Specificities of the Viral Proteases

Mechanism of resistance to U-90152S and sensitization to L-697,661 by a proline to leucine change at residue 236 of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase

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