Details

Autor(en) / Beteiligte

• MOYNA, N. M
• ACKER, G. R
• WEBER, K. M
• FULTON, J. R
• ROBERTSON, R. J
• GOSS, F. L
• RABIN, B. S

Titel

Exercise-induced alterations in natural killer cell number and function

Ist Teil von

• European Journal of Applied Physiology and Occupational Physiology, 1996-09, Vol.74 (3), p.227-233

Ort / Verlag

Berlin: Springer

Erscheinungsjahr

1996

Quelle

MEDLINE

Beschreibungen/Notizen

• To study the effects of exercise on natural killer (NK) cell number and activity (NKCA) healthy male (n = 32) and female (n = 32) subjects were randomly assigned to an exercise or control condition. Exercise involved a continuous incremental protocol consisting of cycling for three periods of 6 min at work rates corresponding to 55%, 70% and 85% peak oxygen uptake (VO2peak). Blood samples were drawn at baseline, at 6 min, 12 min and 18 min during exercise, and at 2 h following completion of exercise. Relative to both baseline and control conditions, exercise resulted in an increase in the number of circulating lymphocytes. The proportion of T cells (CD3+) and B cells (CD19+) significantly decreased, and NK cells (CD3-CD16+CD56+) increased throughout exercise. NKCA increased (P < 0.001) during the initial 6 min of exercise with no further changes observed, despite increases (P < 0.001) in the number and proportion of circulating NK cells during exercise at 70% and 85% VO2peak. Plasma epinephrine and norepinephrine increased (P < 0.001) above baseline at 12 min and 18 min. The changes in NK cell number and function were independent of gender. The results indicate that short-duration low-intensity exercise can significantly increase NK cell number and activity. However, alterations in NK cell number are not accompanied by changes of a similar magnitude in NKCA.