Details

Autor(en) / Beteiligte

• Narang, P K
• Blumhardt, C L
• Doran, A R
• Pickar, D

Titel

Steady-state cerebrospinal fluid transfer of verapamil and metabolites in patients with schizophrenia

Ist Teil von

• Clinical pharmacology and therapeutics, 1988-11, Vol.44 (5), p.550-557

Ort / Verlag

New York, NY: Nature Publishing

Erscheinungsjahr

1988

Quelle

MEDLINE

Beschreibungen/Notizen

• Cerebrospinal fluid (CSF) and plasma levels of verapamil and its two metabolites, norverapamil and D‐620, were measured in seven patients with schizophrenia under steady‐state conditions. Simultaneous sampling of CSF and plasma just before the dose during week 4 of the trial showed that verapamil, norverapamil, and D‐620 partition in the CSF and reflect 7%, 5%, and 12% of the corresponding levels in plasma, respectively. There was a significant decrease in the mean unbound fraction of verapamil in schizophrenic patients as compared with normal subjects (0.058 vs. 0.11; p < 0.001). Estimates of the mean unbound fraction obtained from CSF/plasma verapamil concentrations and the pH partition hypothesis showed excellent agreement with that measured by equilibrium dialysis (0.055 vs. 0.058) in these patients. Although systemic pool protein concentrations in schizophrenic patients were within normal range, an excellent positive correlation was observed between the ratio of the bound/ free verapamil concentration and α1‐acid glycoprotein levels (r = 0.86; p < 0.05). Determination and development of correlations between plasma and GSF may enhance our understanding of the central nervous system effects of verapamil. Clinical Pharmacology and Therapeutics (1988) 44, 550–557; doi:10.1038/clpt.1988.193