Details

Autor(en) / Beteiligte

• Dunnington, E.A. (Virginia Tech, Blacksburg, VA.)
• Briles, W.E
• Briles, R.W
• Siegel, P.B

Titel

Immunoresponsiveness in chickens: association of antibody production and the B system of the major histocompatibility complex

Ist Teil von

• Poultry science, 1996-10, Vol.75 (10), p.1156-1160

Ort / Verlag

England

Erscheinungsjahr

1996

Quelle

MEDLINE

Beschreibungen/Notizen

• Lines of White Leghorn chickens were selected for high or low antibody response to sheep erythrocytes for five generations. The base population from which the experiment started was composed of individuals all of which were heterozygous at the MHC haplotypes B13 and B21. Body weights, egg production traits, and genotypes at the B system were monitored for all individuals in each generation. By Generations 4 and 5 there was separation of the two replicate lines selected for high titer from the two replicate lines selected for low titer. Over the course of the experiment, higher antibody titers and lower BW were associated with B21 and lower antibody titers and higher BW were associated with B13, although these relationships did not occur in every instance. Conclusions were that the B system was associated with antibody response, but that the chickens did not depend entirely upon that association for protection against foreign proteins. Also, the importance of having replicate lines in a selection experiment was shown