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A tandemly repetitive DNA sequence is present at diverse locations in the genome of Ostertagia circumcincta
Ist Teil von
Gene, 1996, Vol.174 (2), p.273-279
Ort / Verlag
Netherlands: Elsevier B.V
Erscheinungsjahr
1996
Quelle
Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)
Beschreibungen/Notizen
A novel repetitive DNA sequence in the sheep parasitic nematode
Ostertagia circumcincta was cloned and sequenced. This 1.2-kb sequence (Oc1B) was not found in the closely related cattle parasite
Ostertagia ostertagi, nor in the more distantly related sheep parasites
Haemonchus contortus or
Trichostrongylus colubriformis. Sequences similar to Oc1B were found at various genomic locations and contained a pair of 33-bp direct repeats. Oc1B also contained a single copy of a 218-bp sequence (designated OcREP) which was present in 100 to 200 copies in the O.
circumcincta genome and mostly organized in distinctive tandem arrays. The dual organizational pattern of OcREP as both a satellite-like sequence as well as interspersed as single copies amongst dissimilar sequences adds to the growing evidence for the fluidity of the parasitic nematode genome, and of eukaryotic genomes in general.