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Australian and New Zealand journal of psychiatry, 1996-08, Vol.30 (4), p.553-556
Ort / Verlag
London, England: SAGE Publications
Erscheinungsjahr
1996
Link zum Volltext
Quelle
Taylor & Francis Journals Auto-Holdings Collection
Beschreibungen/Notizen
Objective: A case of XXYY associated with schizophrenia is presented. Clinical picture: A European male with tall stature, hypogonadism, and mild grade intellectual handicap with significantly lower verbal than performance Intelligence Quotient (IQ) exhibited features of chronic paranoid schizophrenia, along with impulsive aggression.
Treatment and outcome: A trial of testosterone replacement exacerbated aggression. Psychotic symptoms persisted despite antipsychotic therapy. Conclusions: This is perhaps the first report of the XXYY syndrome associated with schizophrenia. The psychosis occurs more often in XXY and XXX than normal subjects, providing a clue to locating a gene predisposing to schizophrenia.