Details

Autor(en) / Beteiligte

• Fincher, Timothy K.
• Yoo, Sun D.
• Player, Mark R.
• Sowell, J. Walter
• Michniak, Bozena B.

Titel

In Vitro Evaluation of a Series of N-Dodecanoyl-l-Amino Acid Methyl Esters as Dermal Penetration Enhancers

Ist Teil von

• Journal of pharmaceutical sciences, 1996-09, Vol.85 (9), p.920-923

Ort / Verlag

New York: Elsevier Inc

Erscheinungsjahr

1996

Quelle

MEDLINE

Beschreibungen/Notizen

• A series of N-dodecanoyl-L-amino acid methyl esters (1–10) and n-pentyl N-acetylprolinate (11) were evaluated for dermal enhancement properties using an in vitro diffusion cell technique. Methods of synthesis of these compounds were described. Enhancers were applied 1h prior to drug treatment. Hydrocortisone was used as the model drug and was applied to excised hairless mouse skin as a saturated suspension in propylene glycol. Enhancement ratios (ER) were determined for permeability coefficient, 24h diffusion cell receptor concentration (Q24), and 24h full-thickness skin steroid content. Controls received no enhancer pretreatment of the skin. N-Dodecanoyl-L-proline (10) showed the highest Q24 value for total steroid (ER 13.7) while N-dodecanoyl-L-phenylalanine (5) showed the highest total steroid skin retention (ER 16.5).