Details

Autor(en) / Beteiligte

• Shi, Guoen
• Gu, Zhe-ming
• He, Kan
• Wood, Karl V.
• Zeng, Lu
• Ye, Qing
• MacDougal, John M.
• McLaughlin, Jerry L.

Titel

Applying Mosher's method to acetogenins bearing vicinal diols. The absolute configurations of muricatetrocin C and rollidecins A and B, new bioactive acetogenins from Rollinia mucosa

Ist Teil von

• Bioorganic & medicinal chemistry, 1996-08, Vol.4 (8), p.1281-1286

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

1996

Quelle

Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)

Beschreibungen/Notizen

• Muricatetrocin C (1), rollidecin A (2), and rollidecin B (3), three new bioactive annonaceous acetogenins bearing vicinal diols, were isolated from the leaves of Rollinia mucosa (Annonaceae) using activity-directed fractionation. The total structural elucidations of 1–3, including the absolute stereochemistries of the vicinal diols, were achieved by analyzing their per-Mosher ester derivatives. All three compounds showed potent and selective inhibitory effects against several human cancer cell lines. Muricatetrocin C, a new mono-THF acetogenin, and rollidecins A and B (1, 2), new adjacent bis-THF acetogenins, were isolated and showed potent and selective cytotoxicities. Analyses of their per-Mosher esters determined their absolute configurations.