Details

Autor(en) / Beteiligte

• Wilton, Joanne C.
• Matthews, Glenn M.

Titel

Polarised membrane traffic in hepatocytes

Ist Teil von

• BioEssays, 1996-03, Vol.18 (3), p.229-236

Ort / Verlag

Hoboken: Wiley Subscription Services, Inc., A Wiley Company

Erscheinungsjahr

1996

Quelle

Wiley Online Library - AutoHoldings Journals

Beschreibungen/Notizen

• The liver was used widely in early studies of polarised transport but has been largely overlooked in recent years, mostly because of the development of epithelial cell lines which provide more tractable experimental systems. The majority of membrane proteins and lipids reach the hepatocyte apical membrane by transcytosis and it remains unclear whether there is a direct route for apical targeting, although the pathways present have yet to be fully characterised. The recent development of systems that allow hepatocyte transport processes to be studied in culture and the observation that transcytosis can be significantly stimulated under physiological conditions suggest that hepatocytes have a role to play in future studies of polarised transport. This review discusses the known features of polarised membrane traffic in hepatocytes and contrasts them with the characteristics of vesicular transport in other epithelial cell types.