Journal of medicinal chemistry, 1996-10, Vol.39 (21), p.4167-4172
1996
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Details
- Autor(en) / Beteiligte
- Titel
- Understanding the Mechanism of Sweet Taste: Synthesis of Ultrapotent Guanidinoacetic Acid Photoaffinity Labeling Reagents
- Ist Teil von
- Journal of medicinal chemistry, 1996-10, Vol.39 (21), p.4167-4172
- Ort / Verlag
- Washington, DC: American Chemical Society
- Erscheinungsjahr
- 1996
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Azido-functionalized analogs of potently sweet guanidinoacetic acids have been synthesized for use as sweetener receptor photoaffinity labeling reagents. These compounds have been synthesized using readily available starting materials. One of the azido-labeled guanidinoacetic acids has been evaluated in an electrophysiological model in the Rhesus monkey. We found that the photoaffinity-labeling reagent caused irreversible inhibition in electrophysiological response to sweeteners upon exposure of the monkey tongue to a combination of the reagent and UV light.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0022-2623eISSN: 1520-4804DOI: 10.1021/jm960349qTitel-ID: cdi_proquest_miscellaneous_78426964
- Format
- –
- Schlagworte
- Affinity Labels - chemical synthesis, Affinity Labels - chemistry, Animals, Aspartame - pharmacology, Biological and medical sciences, Electrophysiology, Fundamental and applied biological sciences. Psychology, Glycine - analogs & derivatives, Glycine - chemical synthesis, Glycine - chemistry, Macaca mulatta, Olfactory system and olfaction. Gustatory system and gustation, Photolysis, Sweetening Agents - pharmacology, Taste - drug effects, Taste - physiology, Thiazines - pharmacology, Tongue - drug effects, Tongue - physiology, Ultraviolet Rays, Vertebrates: nervous system and sense organs