Details

Autor(en) / Beteiligte

• Ader, Jean-Louis
• Tran-Van, Tuan
• Praddaude, Françoise

Titel

Renal Tissue Kallikrein in Newborn and Young SHR

Ist Teil von

• American journal of hypertension, 1988-07, Vol.1 (3-Pt-3), p.53S-55S

Ort / Verlag

United States: Oxford University Press

Erscheinungsjahr

1988

Quelle

MEDLINE

Beschreibungen/Notizen

• Since young SHR excrete less urinary kallikrein than WKY, active and total kallikrein (A and T Kall, respectively) was measured (amidolytic assay) in the renal cortex of both strains. Neither at birth nor at age 4 weeks did renal T Kall differ between SHR and WKY. Renal A Kall was significantly lower in newborn SHR and higher in 4-week-old-SHR than in age-matched WKY. Our results indicate that urinary kallikrein does not accurately reflect the renal enzyme activity. They suggest that SHR exhibit an inherited defect in prokallikrein activation and a secondary defect in the release of tissue kallikrein into urine. Am J Hypertens 1988;1:53S–55S