Details

Autor(en) / Beteiligte

• Yoshida, Tetsuya
• Imai, Toshio
• Takagi, Shin
• Nishimura, Miyuki
• Ishikawa, Izumi
• Yaoi, Takeshi
• Yoshie, Osamu

Titel

Structure and expression of two highly related genes encoding SCM-1/human lymphotactin

Ist Teil von

• FEBS letters, 1996-10, Vol.395 (1), p.82-88

Ort / Verlag

England: Elsevier B.V

Erscheinungsjahr

1996

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• SCM-1/lymphotactin is a chemokine-like molecule produced selectively, if not exclusively, by activated CD8 + T cells. Here we report that there are two highly homologous SCM-1 genes, which we designate as SCM-1α and SCM-1β. Both genes have three exons and two introns. The 1st intron of SCM-1α contains a pseudogene of the ribosomal large subunit L7a. In SCM-1β, a 1.5-kb region including about a quarter of the L7a pseudogene is deleted from the 1st intron. Otherwise, the two genes are highly homologous including the 5′ and 3′ flanking regions. Both genes were mapped to human chromosome 1q23. The two genes were similarly induced in peripheral blood mononuclear cells by mitogenic stimulation. Primer extension and RNase protection revealed several transcription initiation sites. The biological activities of SCM-1α and SCM-1β, which have two amino acid differences at positions 7 and 8 in the mature proteins, remain to be compared.