Neuroscience letters, 1996-06, Vol.211 (3), p.203-206
1996
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- Autor(en) / Beteiligte
- Titel
- Brain-derived neurotrophic factor, but not neurotrophin-3, prevents ischaemia-induced neuronal cell death in organotypic rat hippocampal slice cultures
- Ist Teil von
- Neuroscience letters, 1996-06, Vol.211 (3), p.203-206
- Ort / Verlag
- Shannon: Elsevier Ireland Ltd
- Erscheinungsjahr
- 1996
- Quelle
- Access via ScienceDirect (Elsevier)
- Beschreibungen/Notizen
- We have investigated the neuroprotective actions of neurotrophins in a model of ischaemia using slice cultures. Ischaemia was induced in organotypic hippocampal cultures by simultaneous oxygen and glucose deprivation. Cell death was assessed 24 h later by propidium iodide fluorescence. Pre- but not post-ischaemic addition of brain-derived neurotrophic factor (BDNF) produced a concentration-dependent reduction in neuronal damage. Neurotrophin-3 was not neuroprotective. These data suggest that BDNF may form part of an endogenous neuroprotective mechanism.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0304-3940eISSN: 1872-7972DOI: 10.1016/0304-3940(96)12745-2Titel-ID: cdi_proquest_miscellaneous_78352060
- Format
- –
- Schlagworte
- Animals, Biological and medical sciences, Brain Ischemia - drug therapy, Brain-derived neurotrophic factor, Brain-Derived Neurotrophic Factor - pharmacology, Cell Death - drug effects, Dose-Response Relationship, Drug, Hippocampus, Hippocampus - drug effects, Ischaemia, Medical sciences, Nerve Growth Factors - pharmacology, Neuropharmacology, Neuroprotective agent, Neurotrophin, Organotypic slice culture, Pharmacology. Drug treatments, Propidium iodide, Rats, Rats, Wistar