Details

Autor(en) / Beteiligte

• Kulkosky, P.J.
• Foderaro, M.A.
• Glazner, G.W.
• Niichel, V.I.
• Schnur, P.

Titel

Bombesin-induced grooming in the golden hamster

Ist Teil von

• Behavioural brain research, 1988-07, Vol.29 (1), p.173-177

Ort / Verlag

Shannon: Elsevier B.V

Erscheinungsjahr

1988

Link zum Volltext

Quelle

Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)

Beschreibungen/Notizen

• Lateral cerebroventricular injection of the peptide bombesin (0.01–1.0 μg) promptly elicited excessive grooming and scratching behaviors in home-caged male and female golden hamsters. Bombesin-induced grooming persisted throughout a 60-min observation period at doses of 0.1–1.0 μg. Grooming with forepaws and mouth was more consistently increased than hindleg scratching behaviors. Dependence of this neuropeptide effect on grooming on muscarinic cholinergic activity was assessed by injecting scopolamine (0.001–1 mg/kg) intraperitoneally 15 min prior to 0.1 μg bombesin. Excessive grooming induced by centrally administered bombesin was abolished by 0.1 and 1 mg/kg scopolamine, although basal level of grooming was not significantly affected. The findings indicate a cross-species generality of the dependence of bombesin-induced grooming on muscarinic cholinergic activity, and species-specific differences among rodents in the components of excessive grooming elicited by bombesin.