Genomics (San Diego, Calif.), 1996, Vol.31 (1), p.135-138
1996
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- Autor(en) / Beteiligte
- Titel
- A novel gene, DXS8237E, lies within 20 kb upstream of UBE1 in Xp11.23 and has a different X inactivation status
- Ist Teil von
- Genomics (San Diego, Calif.), 1996, Vol.31 (1), p.135-138
- Ort / Verlag
- San Diego, CA: Elsevier
- Erscheinungsjahr
- 1996
- Quelle
- ScienceDirect
- Beschreibungen/Notizen
- A novel X-linked gene, DXS8237E, was isolated from human fetal brain cDNA, and its 3' end was mapped to within 20 kb upstream of UBE1 in Xp11.23. A 1.3-kb cDNA for DXS8237E detects homologous sequences in other mammals and a 3-kb mRNA that is widely expressed in human cell lines and mouse tissues. Sequence analysis indicated that the 1.3-kb cDNA contains the 3' end of the DXS8237E gene, but the sequence shows no significant homology to known genes. DXS8237E was shown to be subject to X inactivation in five somatic cell hybrids that contain an inactive human X chromosome but no active homologue. Since UBE1 escapes X inactivation, DXS8237E and UBE1 are the closest mapped genes with discordant X inactivation profiles. Sequences in the vicinity of these two genes may be important determinants of X inactivation status.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0888-7543eISSN: 1089-8646DOI: 10.1006/geno.1996.0022Titel-ID: cdi_proquest_miscellaneous_78335073
- Format
- –
- Schlagworte
- Animals, Base Sequence, Biological and medical sciences, Chromosome Mapping, Classical genetics, quantitative genetics, hybrids, Cricetinae, DNA Primers - genetics, DNA, Complementary - genetics, Dosage Compensation, Genetic, Female, Fundamental and applied biological sciences. Psychology, Gene Expression, Genetic Linkage, Genetic Markers, Genetics of eukaryotes. Biological and molecular evolution, Human, Humans, Hybrid Cells, Ligases - genetics, Mice, Molecular Sequence Data, RNA, Messenger - genetics, RNA, Messenger - metabolism, Ubiquitin-Protein Ligases, X Chromosome - genetics