Details

Autor(en) / Beteiligte

• MUTTER, G. L
• BOYNTON, K. A
• FAQUIN, W. C
• RUIZ, R. E
• JOVANOVIC, A. S

Titel

Allelotype mapping of unstable microsatellites establishes direct lineage continuity between endometrial precancers and cancer

Ist Teil von

• Cancer research (Chicago, Ill.), 1996-10, Vol.56 (19), p.4483-4486

Ort / Verlag

Philadelphia, PA: American Association for Cancer Research

Erscheinungsjahr

1996

Quelle

MEDLINE

Beschreibungen/Notizen

• Progressive microsatellite changes in replication error positive (RER+) endometrium were used to reconstruct evolutionary stages of nonfamilial adenocarcinoma. RER+ putative endometrial precancers (atypical endometrial hyperplasias) progress to RER+ carcinomas, which retain some of the altered microsatellites acquired in earlier precursor stages. The RER+ phenotype may provide a specific marker for early-stage endometrial neoplasms that cannot be resolved by routine histopathology and may be a useful tool to stratify stages in the evolution of RER+ tumors.