Biochemical pharmacology, 1988-08, Vol.37 (16), p.3097-3102
1988
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Details
- Autor(en) / Beteiligte
- Titel
- Guanine nucleotide effects on agonist binding to serotonin 5HT2 receptors in rat frontal cortex
- Ist Teil von
- Biochemical pharmacology, 1988-08, Vol.37 (16), p.3097-3102
- Ort / Verlag
- New York, NY: Elsevier Science
- Erscheinungsjahr
- 1988
- Quelle
- Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)
- Beschreibungen/Notizen
- Specific [3H]ketanserin binding to serotonin 5-HT2 receptors of rat frontal cortex tissue is of high affinity, saturable and unaffected by guanine nucleotides. Antagonists displace [3H]ketanserin from a single recognition site (pseudo-Hill coefficients close to unity), which is also unaffected by guanine nucleotides. Agonist displacement of either [3H]ketanserin or [3H]spiperone from three different membrane preparations showed pseudo-Hill coefficients less than one, and may be described in terms of two agonist binding sites with differing agonist affinities. In the presence of guanine nucleotides, overall agonist affinity was lowered slightly, with little or no change in pseudo-Hill coefficient.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0006-2952eISSN: 1873-2968DOI: 10.1016/0006-2952(88)90306-1Titel-ID: cdi_proquest_miscellaneous_78333585
- Format
- –
- Schlagworte
- Animals, Biological and medical sciences, Cerebral Cortex - drug effects, Cerebral Cortex - metabolism, Guanine Nucleotides - pharmacology, Guanosine Triphosphate - pharmacology, Ketanserin - metabolism, Kinetics, Magnesium - pharmacology, Male, Medical sciences, Neuropharmacology, Neurotransmitters. Neurotransmission. Receptors, Pharmacology. Drug treatments, Rats, Receptors, Serotonin - metabolism, Serotoninergic system, Spiperone - metabolism