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Development of anti‐interferon antibodies and breakthrough hepatitis during treatment for HCV infection in haemophiliacs
Ist Teil von
British journal of haematology, 1996-09, Vol.94 (3), p.551-556
Ort / Verlag
Oxford, U.K. and Cambridge, USA: Blackwell Science Ltd
Erscheinungsjahr
1996
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
The development of anti‐interferon antibodies may lead to treatment failure during interferon therapy. We have studied the development of such antibodies in a group of 39 haemophiliacs receiving interferon‐α2a for chronic hepatitis C virus (HCV) infection. Anti‐interferon antibodies developed in five (13%) patients and were associated with ‘breakthrough hepatitis’ in three cases. There was an association between the development of anti‐interferon antibodies and infection with HCV genotype 3a (P= 0 .01). This study suggests that the development of anti‐interferon antibodies may lead to treatment failure in a proportion of haemophiliacs with HCV infection. The association with genotype 3a has not previously been reported. Monitoring for the development of breakthrough hepatitis due to anti‐interferon antibodies may provide the opportunity to develop strategies to overcome their effects.