Details

Autor(en) / Beteiligte

• Bentick, Bernard
• Shaw, Robert W.
• Iffland, Claire A.
• Burford, Graham
• Bernard, Albert

Titel

A randomized comparative study of purified follicle stimulating hormone and human menopausal gonadotropin after pituitary desensitization with Buserelin for superovulation and in vitro fertilization

Ist Teil von

• Fertility and sterility, 1988-07, Vol.50 (1), p.79-84

Ort / Verlag

New York, NY: Elsevier Inc

Erscheinungsjahr

1988

Quelle

MEDLINE

Beschreibungen/Notizen

• Twenty patients entered a randomized, crossover study of purified follicle-stimulating hormone (pure-FSH) or human menopausal gonadotropin (hMG) superovulation, 2 ampules per day after pituitary desensitization with the luteinizing hormone–releasing hormone (LH-RH) analogue Buserelin (D-Ser tBu6 LH-RH 1-9 ethylamide) nasal spray. There were no cycles cancelled. Six patients conceived (five on pure-FSH, one on hMG). There were 24.2±2.5 (mean±standard error of the mean [SEM]) ampules of pure-FSH and 24.3±3.6 ampules of hMG stimulation required. There were similar numbers of preoperation follicles: 6.9±1.0 on hMG and 6.6±1.1 on pure-FSH, of oocytes collected; 8.5±1.4 on hMG and 5.8±1.4 on pure-FSH, and of pre-embryos achieved; 5.1±0.9 on hMG and 3.4±1.0 on pure-FSH; on either treatment. The fertilization rate on hMG was 60% and on pure-FSH was 55%. Pre-embryo transfer rates were 3.2±0.3 in the hMG group and 2.7±0.4 in the pure-FSH group. There were no differences in serum FSH, LH, estradiol, or progesterone levels between the hMG and pure-FSH groups. Mean±SEM luteal phase length was 10.6±0.4 days in the nonpregnant cycles.