Details

Autor(en) / Beteiligte

• Platt, Orah S
• Guinan, Eva C

Titel

Bone Marrow Transplantation in Sickle Cell Anemia — The Dilemma of Choice

Ist Teil von

• The New England journal of medicine, 1996-08, Vol.335 (6), p.426-428

Ort / Verlag

United States: Massachusetts Medical Society

Erscheinungsjahr

1996

Quelle

Electronic Journals Library

Beschreibungen/Notizen

• The clinical complications of sickle cell anemia reflect the vascular damage caused by the abnormal red cells. Filled with hemoglobin S, sickle red cells obstruct and injure vessels when the abnormal hemoglobin polymerizes, is denatured, and releases toxic oxidants. The process insidiously affects vulnerable vascular beds in the spleen, brain, lung, kidney, eye, and heart. Except for the spleen and brain, where the complications may have a developmental component and arise in childhood, the compromise of most organs takes decades to develop. About 20 percent of deaths in sickle cell anemia occur in patients with chronic organ failure. The distressing, . . .