Details

Autor(en) / Beteiligte

• LEE, S.-D
• CHAN, C.-Y
• YU, M.-I
• WANG, Y.-J
• LO, K.-J
• SAFARY, A

Titel

Single dose-inactivated hepatitis A vaccination schedule for susceptible youngsters

Ist Teil von

• The American journal of gastroenterology, 1996-07, Vol.91 (7), p.1360-1362

Ort / Verlag

Oxford: Blackwell Publishing

Erscheinungsjahr

1996

Quelle

MEDLINE

Beschreibungen/Notizen

• To investigate the feasibility of a single-dose primary hepatitis A vaccination for young travelers. One hundred and nineteen susceptible youngsters, 9-18 yr old, received a dose of 720 ELISA units of the inactivated hepatitis A vaccine at month 0, and then a booster at month 6. Antibodies to hepatitis A virus (anti-HAV) seroconversion ( > or = 20 mIU/ml) in these vaccinees was 91% (106/117) on day 15, and reached 99% (118/119) 1 month after the single-dose vaccination. At month 6 before the booster, 97% (110/113) of the vaccinees still had detectable anti-HAV. All vaccinees (113/113) had measurable titers of anti-HAV 1 month after booster vaccination, and were still seropositive (68/68) at month 12. The anti-HAV response was found to be slower in vaccinees positive for hepatitis B surface antigen (11/16, 68.8%), compared with noncarrier vaccinees (95/101, 94.1%; p < 0.01) 15 days after the priming dose. After initial vaccination, the geometric mean titers of anti-HAV among vaccine responders were 220, 255, 117, 3308, and 1094 mIU/ml at day 15 and months 1, 6, 7, and 12, respectively. These results suggest that a single dose of hepatitis A vaccine could be a good alternative to immune serum globulin administration for immunoprophylaxis in young healthy travelers.