Details

Autor(en) / Beteiligte

• Abraham, Wickliffe C.
• Bear, Mark F.

Titel

Metaplasticity: the plasticity of synaptic plasticity

Ist Teil von

• Trends in neurosciences (Regular ed.), 1996-04, Vol.19 (4), p.126-130

Ort / Verlag

Oxford: Elsevier Ltd

Erscheinungsjahr

1996

Quelle

Access via ScienceDirect (Elsevier)

Beschreibungen/Notizen

• In thi paper, we review experimental evidence for a novel form of persistent synaptic plasticity we call metaplasticity. Metaplasticity is induced by synaptic or cellular activity, but it is not necessarilly expressed as a change in the efficacy of normal synaptic transmission. Instead, it is manifest as a change in the ability to induce subsequent synaptic plasticity such as long-term potentiation or depression, Thus metaplasticity is higher-order form of synaptic plasticity. Metaplasticity might involve alterations in NMDA-receptor function in some cases, but there are many other candidate mechanisms. The induction of metaplasticity complicates the interpretation of many commonly studied aspects of synaptic plasticity, such as saturation and biochemical correlates.