The Journal of biological chemistry, 1996-04, Vol.271 (14), p.7883-7886
1996
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- Autor(en) / Beteiligte
- Titel
- Rac-dependent and -independent pathways mediate growth factor-induced Ca2+ influx
- Ist Teil von
- The Journal of biological chemistry, 1996-04, Vol.271 (14), p.7883-7886
- Ort / Verlag
- United States
- Erscheinungsjahr
- 1996
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- We report that expressing interfering mutants of the small Ras-related GTPase Rac, using either recombinant vaccinia virus or stable DNA transfection, eliminates epidermal growth factor-induced Ca2+ signaling, without affecting Ca2+ mobilization or influx from G protein-coupled receptors. Platelet-derived growth factor-dependent Ca2+ influx, however, is only partly sensitive to dominant negative Rac proteins. Thus, whereas epidermal growth factor-induced Ca2+ influx is completely mediated by Rac proteins, platelet-derived growth factor-induced Ca2+ influx involves Rac-dependent and -independent signaling pathways.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0021-9258DOI: 10.1074/jbc.271.14.7883Titel-ID: cdi_proquest_miscellaneous_78033799
- Format
- –
- Schlagworte
- Animals, Calcium - physiology, Cells, Cultured, Epidermal Growth Factor - physiology, ErbB Receptors - physiology, GTP-Binding Proteins - physiology, HeLa Cells, Histamine - pharmacology, Humans, Platelet-Derived Growth Factor - physiology, rac GTP-Binding Proteins, Rats, Receptors, Platelet-Derived Growth Factor - physiology, Recombinant Proteins, rho GTP-Binding Proteins, Signal Transduction, Vaccinia virus