Details

Autor(en) / Beteiligte

• Iaizzo, Paul A.
• Kehler, Chris H.
• Carr, Richard J.
• Sessler, Daniel I.
• Belani, Kumar G.

Titel

Prior Hypothermia Attenuates Malignant Hyperthermia in Susceptible Swine

Ist Teil von

• Anesthesia and analgesia, 1996-04, Vol.82 (4), p.803-809

Ort / Verlag

Hagerstown, MD: International Anesthesia Research Society

Erscheinungsjahr

1996

Quelle

MEDLINE

Beschreibungen/Notizen

• This study was designed to determine the extent by which mild or moderate hypothermia attenuates the triggering of malignant hyperthermia (MH) induced by the combined administration of halothane and succinylcholine.Sixteen susceptible swine were initially anesthetized with nontriggering drugs and then either kept normothermic (approximate equals 38 degrees C, n = 6) or cooled to induce mild (approximate equals 35 degrees C, n = 6), or moderate (approximate equals 33 degrees C, n = 4) hypothermia. Next, after a 30-min control period, the normothermic and mildly hypothermic animals were administered 1 minimum alveolar anesthetic concentration (MAC) halothane followed by a bolus dose of succinylcholine (2 mg/kg). Within 10 min all normothermic animals developed fulminant MH, whereas the onset of MH was slowed or was absent in the mildly hypothermic group. To test whether moderate hypothermia could more effectively minimize the signs of a MH episode, this group of animals was exposed to 1.5 MAC halothane followed 10 min later by a 3-mg/kg bolus of succinylcholine. MH was not induced and anesthesia was then changed to nontriggering drugs (ketamine and pancuronium). The animals were then aggressively rewarmed to 38 degrees Ca slight increase in the ETCO2 was detected, but MH episodes did not spontaneously occur. Subsequently, the readministration of halothane and succinylcholine rapidly provoked fulminant MH. We concluded that the induction of mild hypothermia impairs triggering and reduces the progression of MH induced by the combined administration of halothane and succinylcholine, whereas moderate hypothermia was completely protective and thus could be considered for prophylaxis.(Anesth Analg 1996;82:803-9)