The Journal of infectious diseases, 1996-03, Vol.173 (3), p.542-549
1996
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Details
- Autor(en) / Beteiligte
- Titel
- Human Herpesvirus 8 Is Present in the Lymphoid System of Healthy Persons and Can Reactivate in the Course of AIDS
- Ist Teil von
- The Journal of infectious diseases, 1996-03, Vol.173 (3), p.542-549
- Ort / Verlag
- Chicago, IL: The University of Chicago Press
- Erscheinungsjahr
- 1996
- Quelle
- Oxford Journals 2020 Medicine
- Beschreibungen/Notizen
- In this study the prevalence of human herpesvirus (HHV) 8 DNA was determined in biopsies from persons with lymphoproliferative disorders and in peripheral blood mononuclear cells (PBMC) from human immunodeficiency virus (HIV)-seronegative and HIV-infected persons. The results show that HHV-8 is present in ∼10% of biopsies from HIV-seronegative persons; HHV-8 is detected with similar prevalence values in HIV-infected patients with lymphoproliferative diseases, but the virus load is higher. HHV-8 was also found in PBMC. The presence of monoclonal Epstein-Barr virus (EBV) genomes in malignant lymphoproliferations was only infrequently associated with HHV-8 infection. Therefore,HHV-8 is fairly common in the population, and the lymphoid system could represent a reservoiroflatently infected cells from which the virusmay reactivate in conditions of immunodepression; furthermore, HHV-8 and EBVdo not seem to act in conjunction in lymphomagenesis.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0022-1899eISSN: 1537-6613DOI: 10.1093/infdis/173.3.542Titel-ID: cdi_proquest_miscellaneous_78011578
- Format
- –
- Schlagworte
- Acquired Immunodeficiency Syndrome - virology, AIDS-Related Opportunistic Infections - complications, AIDS-Related Opportunistic Infections - virology, AIDS/HIV, Base Sequence, Biological and medical sciences, DNA, DNA Primers - genetics, DNA, Viral - genetics, DNA, Viral - isolation & purification, Epstein Barr virus infections, Herpesviridae, Herpesviridae - genetics, Herpesviridae - isolation & purification, Herpesviridae - pathogenicity, Herpesviridae Infections - complications, Herpesviridae Infections - virology, Herpesvirus 4, Human - genetics, Herpesvirus 4, Human - isolation & purification, HIV, HIV Seronegativity, Hodgkin disease, Human herpesvirus 8, human immunodeficiency virus, Human viral diseases, Humans, Infectious diseases, Leukocytes, Mononuclear - virology, Lymphoid Tissue - virology, Lymphoma, Lymphoproliferative Disorders - complications, Lymphoproliferative Disorders - virology, Major Articles, Medical sciences, Miscellaneous, Molecular Sequence Data, Nucleotide sequences, Polymerase chain reaction, Polymerase Chain Reaction - statistics & numerical data, Sensitivity and Specificity, Viral diseases, Viruses