Details

Autor(en) / Beteiligte

• Yaswen, L
• Kulkarni, A B
• Fredrickson, T
• Mittleman, B
• Schiffman, R
• Payne, S
• Longenecker, G
• Mozes, E
• Karlsson, S

Titel

Autoimmune manifestations in the transforming growth factor-beta 1 knockout mouse

Ist Teil von

• Blood, 1996-02, Vol.87 (4), p.1439-1445

Ort / Verlag

United States

Erscheinungsjahr

1996

Quelle

MEDLINE

Beschreibungen/Notizen

• Targeted disruption of the transforming growth factor-beta 1 (TGF-beta 1) gene in mice results in the development of a massive multifocal inflammatory disease in many tissues. Because no detectable pathogen was identified, we examined whether autoimmune mechanisms played a role in initiating or maintaining the inflammatory disease. The serum of TGF-beta 1 knockout mice contained elevated titers of antibodies to nuclear antigens (ssDNA, dsDNA, Sm, and RNP) as well as reactivity against the 16/6 idiotype (16/6 Id). In addition, Ig deposits were detected in renal glomeruli of TGF- beta 1 knockout mice. Transplantation of TGF-beta 1 knockout hematopoietic cells into normal irradiated recipients resulted in a similar profile of autoantibody production as well as in the induction of inflammatory lesions. Our results describe autoimmune activity that ensues when the TGF-beta 1 cytokine is absent.