Details

Autor(en) / Beteiligte

• Chang, Huan J.
• Christenson, John C.
• Pavia, Andrew T.
• Bobrin, Brad D.
• Bland, Lee A.
• Carson, Loretta A.
• Arduino, Matthew J.
• Verma, Punam
• Aguero, Sonia M.
• Carroll, Karen
• Jenkins, Eileen
• Daly, Judy A.
• Woods, Marion L.
• Jarvis, William R.

Titel

Ochrobactrum anthropi Meningitis in Pediatric Pericardial Allograft Transplant Recipients

Ist Teil von

• The Journal of infectious diseases, 1996-03, Vol.173 (3), p.656-660

Ort / Verlag

Chicago, IL: The University of Chicago Press

Erscheinungsjahr

1996

Link zum Volltext

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• An epidemiologic investigation was done after 3 patients contracted Ochrobactrum anthropi meningitis at one hospital in October 1994. Neurosurgical patients with pericardial tissue implants were at greater risk of infection than other neurosurgical patients (3/14 vs. 0/566; P < .001). Cultures of implants removed from 2 case-patients, an implant at implantation, a nonimplanted pericardial tissue, and an unwrapped but unopened bottle of Hanks' balanced salt solution (HBSS) grew O. anthropi. Patient and tissue isolates had identical genotypes; the isolate from the HBSS bottle had a unique genotype. Culture samples from an unopened HBSS bottle and from pericardial tissue grew Pseudomonas stutzeri of the same genotype; however, no P. stutzeri infections were detected. The investigation documented intrinsic P. stutzeri contamination of HBSS. O. anthropi contamination of tissues occurred during processing, possiblydue to extrinsic contamination of HBSS. Active surveillance is needed to detect infection in patients receiving transplanted tissues, and rigorous infection control practices are necessary during tissue harvesting and processing to ensure sterility.