Details

Autor(en) / Beteiligte

• Considine, R.V
• Sinha, M.K
• Heiman, M.L
• Kriauciunas, A
• Stephens, T.W
• Nyce, M.R
• Ohannesian, J.P
• Marco, C.C
• McKee, L.J
• Bauer, T.L

Titel

Serum immunoreactive-leptin concentrations in normal-weight and obese humans

Ist Teil von

• The New England journal of medicine, 1996-02, Vol.334 (5), p.292-295

Ort / Verlag

Boston, MA: Massachusetts Medical Society

Erscheinungsjahr

1996

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Background. Leptin, the product of the ob gene, is a hormone secreted by adipocytes. Animals with mutations in the ob gene are obese and lose weight when given leptin, but little is known about the physiologic actions of leptin in humans. Methods. Using a newly developed radioimmunoassay, we measured serum concentrations of leptin in 136 normal-weight subjects and 139 obese subjects (body-mass index, greater than or equal to 27.3 for men and greater than or equal to 27.8 for women the body-mass index was defined as the weight in kilograms divided by the square of the height in meters). The measurements were repeated in seven obese subjects after weight loss and during maintenance of the lower weight. The ob messenger RNA (mRNA) content of adipocytes was determined in 27 normal-weight and 27 obese subjects.